By Lennart Philipson (auth.), Professor Dr. Walter Doerfler (eds.)
A perplexing epidemiological challenge used to be the driver at the back of the invention of human adenoviruses by means of Wallace Rowe and his colleagues 30 years in the past. The de velopment of a plaque assay for poliomyelitis virus in 1953 led us to the brink of quantitative virology, and within the similar 12 months the double-helical constitution of DNA used to be came across and have become a cornerstone of mo lecular biology. the possibility of adenoviruses as learn instruments within the molecular and mobile biology of eukaryotic cells was once well-known as early because the overdue Fifties and early Sixties by means of a number of investigators. Structural and biochemical stu dies ruled the early years. In 1962, a few of the adenoviruses have been the 1st human viruses proven to be oncogenic in experimental animals. hence adenovirology provided the investigator the complete gamut of host cellphone interactions, efficient and abortive, in addition to trans shaped and tumor mobile structures. the probabilities that adenoviruses afforded for the examine of the molecular biology and genetics of eukaryotic cells have been absolutely rea lized within the past due Sixties and the 1970s.
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