By Rui Wang (auth.), Rui Wang MD, PhD, FAHA (eds.)
Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play an important position within the biomedical, scientific, and healthiness sciences, in addition to in inhabitants health and wellbeing experiences. In sign Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and drugs, a panel of unusual researchers and clinicians assessment the organic and biomedical points of gasotransmitters, emphasizing their signaling transduction mechanisms regularly, and ion channel law particularly. The authors talk about the endogeneous metabolism and rules of gasotransmitters, their toxicological profiles and organic activities, and their interactions when it comes to their creation and results. The physiological roles of NO, CO, and H2S within the legislation of the cardiovascular, neuronal, and gastrointestinal structures, in addition to of mobile metabolism, also are reviewed, in addition to the interplay of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. integrated within the array of other mechanisms for the interplay of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and adjusted mobile redox prestige. The authors additionally provide advice and recommendations for exploring and extra characterizing different nonetheless unknown gasotransmitters.
Authoritative and finished, sign Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and drugs deals scientific scientists and physicians not just a deeper realizing, but in addition a state of the art evaluation, of the severely vital box of gasotransmitter biology and medicine.
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